一、个人简介
侯晓月,女,1990年10月生,副教授,硕士生导师。
E-mail: 2020000057@jou.edu.cn
通讯地址:连云港市海州区苍梧路59号新葡的京集团3512vip食品科学与工程学院
二、研究方向
(1)海洋微生物资源的开发及应用;
(2)海洋功能性蛋白质的挖掘及应用;
(3)农业微生物及其杀虫蛋白的挖掘及应用。
三、教育经历
2009.09-2013.06,天津科技大学,生物工程专业,本科;
2013.09-2016.03,天津科技大学,轻工技术与工程专业,硕士;
2017.09-2020.06,南开大学,微生物专业,博士。
四、工作经历
2016.03-2017.03,康龙化成(北京)新药技术股份有限公司,生物研究员;
2020.08至今,新葡的京集团3512vip,新葡的京集团3512vip。
五、社会兼职
国家自然科基金项目评审专家
六、代表性科研项目
(1)国家自然科学基金青年基金,营养期杀虫蛋白Vip3Aa结构域III对其功能的影响及机制研究,2022.01-2024.12,主持;
(2)江苏省自然科学基金青年基金,营养期杀虫蛋白Vip3Aa结构域III对其杀虫特异性和杀虫活性的影响及机制研究,2021.07-2024.06,主持;
(3)中国博士后基金面上项目,营养期杀虫蛋白Vip3Aa结构域IV和V对其杀虫活性的影响及机制研究,2023.07-2024.12,主持;
(4)连云港市博士后科研资助A类,营养期杀虫蛋白Vip3Aa结构域III loops影响其杀虫活性的机制研究,2022.07-2023.12,主持;
(5)生物酶法催化鸡骨粉制备鲜味肽,横向课题,2022.02-2023.12,主持。
七、代表性科研论文
(1)Hou Xiaoyue, Li Mengjiao, Mao Chengjuan, Jiang Lei, Zhang Wen, Li Mengying, Geng Xiaomeng, Li Xin, Liu Shu, Yang Guang, Fang Yaowei, Cai Jun*. Domain III β4–β5 Loop and β14–β15 loop of Bacillus thuringiensis Vip3Aa are involved in receptor binding and toxicity. Toxins, 2024, 16(1): 23-39.
(2)He Fuxiang, Bian Yingying, Zhao Yaling, Xia Mengjie, Liu Shu, Gui Jiajin, Hou Xiaoyue*, Fang Yaowei*. In vitro conversion of ellagic acid to urolithin A by different gut microbiota of urolithin metabotype A. Applied Microbiology and Biotechnology, 2024, 108: 215-229.
(3)Liu Qitong, Bian Yingying, Mu Shuting, Chen Meng, Liu Shu, Yang Guang, Huang Yichen, Hou Xiaoyue*, Fang Yaowei*. Genomic and phenotypic-based safety assessment and probiotic properties of Streptococcus thermophilus FUA329, a urolithin A-producing bacterium of human milk origin. Genomics, 2023, 115: 110724-11.
(4)Li Mengjiao, Mao Chengjuan, Li Xin, Jiang Lei, Zhang Wen, Li Mengying, Liu Huixue, Fang Yaowei, Liu Shu, Yang Guang, Hou Xiaoyue*. Edible insects: a new sustainable nutritional resource worth promoting. Foods, 2023, 12: 4073-4157.
(5)Mi Haoyu, Liu Shu, Hai Yang, Yang Guang, Lu Jing, He Fuxiang, Zhao Yaling, Xia Mengjie, Hou Xiaoyue*, Fang Yaowei. Lactococcus garvieae FUA009, a novel intestinal bacterium capable of producing the bioactive metabolite urolithin a from ellagic acid. Foods, 2022, 11: 2621-2637.
(6)Qinwen Ye, Yaowei Fang, Mengjiao Li, Haoyu Mi, Shu Liu, Guang Yang, Jing Lu, Yaling Zhao, Qitong Liu, Wei Zhang, Xiaoyue Hou*. Characterization of a novel myrosinase with high activity from marine bacterium Shewanella baltica Myr-37. International Journal of Molecular Science, 2022, 23,11258.
(7)Hou Xiaoyue, Han Lu, An Baojv, Cai Jun*. Autophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells. Virulence, 2021, 12(1): 509-519.
(8)Hou Xiaoyue, Han Lu, An Baojv, Cao Zhanglei, Zhan Yunda, Cai Xia, Yan Bing, Cai Jun*. Mitochondria and lysosomes participate in Vip3Aa-induced Spodoptera frugiperda Sf9 cell apoptosis. Toxins, 2020, 12(2): 116-130.
(9)Jiang Kun#, Hou Xiaoyue#, Han Lu, Tan Tongtong, Cao Zhanglei, Cai Jun*. Fibroblast growth factor receptor, a novel receptor for vegetative insecticidal protein Vip3Aa. Toxins, 2018, 10(12): 546.
(10)Hong Kunqiang#, Hou Xiaoyue#, Hao Aili, Wang Pengfei, Fu Xiaomeng, Lv Ang, Jian Dong*. Truncation of CYR1 promoter in industrial ethanol yeasts for improved ethanol yield in high temperature condition. Process Biochemistry, 2017, 65(2018): 37-45.
(11)王露露,房耀维,刘姝,杨光,吴新财,陈静*,侯晓月*. 一株感染家蚕的高致病性白僵菌的筛选及发酵条件优化. 微生物学通报, 2022, 49(6): 2233-2244.
八、代表性专利
(1)一株高耐受酿酒酵母菌株及其构建方法, CN201610020542.4。
(2)一株高产酯酿酒酵母菌株及其启动子无缝插入方法, ZL2014131005A.。
(3)获得杀虫活性提高的Vip3Aa突变体的方法及其突变体蛋白, CN2023112612506.